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KMID : 0376219770140010021
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Chonnam Medical Journal
1977 Volume.14 No. 1 p.21 ~ p.26
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Effects of Diabetes Mellitus on the Phagocytic Function of the Reticuloendothelial System
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Abstract
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In order to study alterations of the reticuloendothelial function by diabetes mellitus, the phagocytic activity was assessed by means of carbon clearance method in the streptozotocin-induced diabetic rats. The effects of streptozotocin on the blood sugar level and pancreatic islets were commented also.
l. Beta cells of the pancreatic islets disclosed generally atrophic or necrotic changes from the first day after streptozotocin administration. Alpha cells and acini, however, preserved their normal structure during the whole experi-mental period (3 weeks). Regenerative process of the beta cells could not be observed up to 3 weeks after streptozotocin administration.
2. Streptozotocin caused marked increase in fasting blood glucose level, which did not return to normal level until 3 weeks after streptozotocin administration.
3. The phagocytic activity increased significantly by 1 week (the corrected phagocytic index at 1 week was 10. 5 in the experimental group, comparing with 7.4 in the control group. Thereafter, it decreased steadily, but was still above the control value even at the end of the experimental period.
4. From the above results, it was considered that the alterations in the phagocytic activity was probably due to stimulation. of lipid and protein metabolism by altered carbohydrate metabolism and also due to the relatively increased activity of insulin antagonists, such as growth hormone or ACTH. The increased activity of the reticuloendothelial function observed was thought to play a major role in restoring the altered metabolism and disturbed ;body defense in the diabetic rats.
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